Table 2.
Reduced incidence of spontaneous bleeding by prophylactic administration of factor IX (FIX) compared with ‘on-demand’ treatment in haemophilia B dogs (based on Russell et al. 2003 [1], with permission). This research was originally published in Blood. Russell KE, Olsen EHN, Raymer RA, Merricks EP, Bellinger DA, Read MS, Rup BJ, Keith JC Jr, McCarthy KP, Schaub RG, Nichols TC. Reduced bleeding events with subcutaneous administration of recombinant human factor IX in immune-tolerant haemophilia B dogs. Blood 2003; 102: 4393–8. © The American Society of Hematology.
| Haemophilia B dogs | Bleeding events per year
|
|
|---|---|---|
| 0–1 year | 1–3.5 years | |
| On-demand (n) | 5.5 ± 3.3 (10) | 4.1 ± 3.6 (6) |
| Prophylactic (n) | 1.8 ± 0.5 (5) | 2.1 ± 1.0 (4) |
| Reduction (%) | 69 | 49 |
| P-value | 0.0007 | 0.44 |