Table 1.
Characteristics of Study Population by Type 1 Diabetes Status
| Variable | DM (n = 506) | Non-DM (n = 591) | P value |
|---|---|---|---|
| Lp-PLA2 | |||
| Mass (ng/mL) | 285.3 ± 79.2 | 277.6 ± 77.7 | 0.1 |
| Activity (nmol/min/mL) | 137.2 ± 29.5 | 145.9 ± 35.6 | <0.0001 |
| Age (years) | 36.8 ± 8.9 | 39.8 ± 8.8 | <0.0001 |
| Male (%) | 46% | 51% | 0.38 |
| Total cholesterol (mg/dL) | 173.6 ± 33.4 | 191.5 ± 36.6 | <0.0001 |
| LDL cholesterol (mg/dL) | 99.4 ± 28.2 | 115.7 ± 32.8 | <0.0001 |
| HDL cholesterol (mg/dL) | 56.3 ± 16.3 | 51.4 ± 14.5 | <0.0001 |
| Triglycerides (mg/dL) | 89.8 (25–398) | 121.6 (27–400) | <0.0001 |
| BMI (kg/m2) | 26.1 ± 4.3 | 25.9 ± 4.8 | 0.61 |
| Average waist (cm) | 84.8 ± 12.2 | 85.6 ± 14.1 | 0.33 |
| Visceral fat at L4–L5 (cm2) | 10.3 (8–12) | 10.6 (8–12) | <0.0001 |
| Subcutaneous fat at L4–L5 (cm2) | 11.7 (9–13) | 11.7 (10–13) | 0.64 |
| CRP (μg/mL) | 2.0 ± 2.5 | 1.7 ± 1.8 | 0.06 |
| Progression | 23.5% | 10.0% | <0.0001 |
| Baseline CAC | 48.6 ± 216.0 | 12.8 ± 67.8 | <0.0001 |
| Smoking | |||
| Current | 10.2% | 9.2% | 0.56 |
| Ever | 30.4% | 30.9% | 0.87 |
| Statin use | 14.2% | 4.0% | <0.0001 |
| Hypertension | 40.2% | 14.6% | <0.0001 |
BMI, body mass index; CAC, coronary artery calcium; CRP, C-reactive protein; DM, diabetes mellitus; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Lp-PLA2, lipoprotein-associated phospholipase A2.