Table 1. Model parameter and distributions.

Parameter	Mean	Low	High	s.d.	Distribution	Alpha	Beta	Lambda	Source
Event probabilities
Probability of failure for hospital IV	0.082	0.048	0.109	0.01525	Beta	26.46	296.22		Hidalgo et al, 1999; Innes et al, 2003; Rapoport et al, 1999
Probability of failure for early discharge	0.175	0.152	0.208	0.014	Beta	128.73	606.88		Innes et al, 2003; Sebban et al, 2008
Probability of failure for outpatient IV	0.111	0.047	0.25	0.05075	Beta	4.14	33.17		Minotti et al, 1999; Rubenstein et al, 1993
Probability of failure for outpatient oral	0.189	0.095	0.208	0.02825	Beta	36.11	154.95		Hidalgo et al, 1999; Malik et al, 1995; Minotti et al, 1999; Rubenstein et al, 1993
Probability of readmission for early dischargea	0.5	0.25	0.75	0.125	Beta	7.50	7.50		Innes et al, 2003; Sebban et al, 2008
Probability of readmission for outpatient IVa	‘0.01	0	0.5		Triangular				Rapoport et al, 1999; Rubenstein et al, 1993
Probability of readmission for outpatient POa	0.853	0.75	0.938	0.047	Beta	47.57	8.20		Hidalgo et al, 1999; Malik et al, 1995; Rubenstein et al, 1993
Rate of HCRI	0.006	0.0045	0.0075	0.00075	Normal				Kamboj and Sepkowitz, 2009
Relative risk of HCRI for outpatient IV	0.2	0.15	0.25	0.025	Normal				Simon et al, 2000
Relative risk of HCRI for outpatient oral	0.1	0.075	0.125	0.0125	Normal				Sewonou et al, 2002; Simon et al, 2000
Utilities
Utility for inpatient IV	0.65	0.08	1	0.23	Beta	2.15	1.16		U
Utility for early discharge	0.72	0.16	1	0.21	Beta	2.57	1.00		U
Utility for outpatient IV	0.75	0.05	1	0.2375	Beta	1.74	0.58		U
Utility for outpatient oral	0.72	0	1	0.25	Beta	1.60	0.62		U
Relative reduction (factor) for utility if failure	0.8	0.6	1	0.1	Normal				Assumed
Relative reduction (factor) for utility if HCRIb	0.5	0.375	0.625	0.0625	Normal				Assumed
Relative reduction (factor) for utility if readmission	0.5	0.375	0.625	0.0625	Normal				Brown et al, 2001
Costs
Costs per inpatient stay per day	2000	1000	4000	750	Gamma	7.11		0.0036	C
Costs of initial consultation	460	230	920	172.5	Gamma	7.11		0.0155	C
Costs for outpatient visit	320	160	640	120	Gamma	7.11		0.0222	C
Costs of home care nurse per visit	90	45	180	33.75	Gamma	7.11		0.0790	C
Costs of first-line IV antibiotics per day	100	50	200	37.5	Gamma	7.11		0.0711	C
Costs of second-line IV antibiotics per day	260	130	520	97.5	Gamma	7.11		0.0274	C
Costs of oral antibiotics per day	5	2.50	10	1.875	Gamma	7.11		1.4222	C
Relative increase in costs of antibiotics for HCRIb	1.5	1.125	1.875	0.1875	Normal				Assumed
Time parameter
Duration of inpatient stay for hospital IV	6	3	12	2.25	Gamma	7.11		1.1852	Rapoport et al, 1999
Duration of inpatient stay for early discharge	2	1	4	0.75	Gamma	7.11		3.5556	Innes et al, 2003; Rapoport et al, 1999; Sebban et al, 2008
Duration of outpatient treatment for early discharge	4	2	8	1.5	Gamma	7.11		1.7778	Rapoport et al, 1999; Sebban et al, 2008
Duration of outpatient treatment	6	3	12	2.25	Gamma	7.11		1.1852	Rapoport et al, 1999; Rubenstein et al, 1993; Sebban et al, 2008
Prolongation of therapy related to complicationc	6	3	12	2.25	Gamma	7.11		1.1852	Assumed
Time to complicationc	3	1.5	6	1.125	Gamma	7.11		2.3704	Hidalgo et al, 1999; Innes et al, 2003; Malik et al, 1995; Minotti et al, 1999; Rapoport et al, 1999; Rubenstein et al, 1993; Sebban et al, 2008
Time to complication for early discharge at homec	1	0.5	2	0.375	Gamma	7.11		7.1111	Assumed

C: costs were obtained from local finance offices and the Department of Pharmacy at Princess Margaret Hospital in Toronto, Ontario/Canada.

U: utilities (visual analogue scale scores, converted into standard gamble utilities) were derived from 77 adult cancer patients at Princess Margaret Hospital in Toronto, Ontario/Canada.

^aConditional on failure of therapy.

^bHealthcare-related infection.

^cComplication=failure, readmission, healthcare-related infection.

Note: the probability of readmission for outpatient IV was 0% based on two published RCTs; however, to apply a reasonable distribution to this variable ( → triangular), a peak estimate of 1% (0.01) was chosen.