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. 2011 Apr 26;104(9):1459–1471. doi: 10.1038/bjc.2011.111

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Copyright © 2011 Cancer Research UK

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p53 staining patterns in normal epidermis and SCC and association with Bag-1 expression. (A and B) p53 expression in normal epidermis. Normal skin is predominantly negative for p53, with some occasional p53-positive cells. A small number of p53-positive cells can be seen (arrowheads in B). (C) Negative control tumour section without primary antibody (NGS in PBS alone); (D) corresponding p53 stained section showed 60% of cells p53 positive; assigned a score of +++ nuclear staining. (E) p53 shows strong nuclear staining in skin SCC. (G) Corresponding area of the same tumour showing moderate nuclear and weak cytoplasmic Bag-1 staining. (F and H) Higher-power images of the boxed areas in images E and G highlight the presence of predominantly nuclear p53 and Bag-1 staining, respectively. Images A, E and G were photographed using a × 10 objective (scale bar shown in A), images B, D, F and H were photographed using a × 40 objective (scale bar shown in B) and image C was photographed using a × 20 objective (scale bar shown). (I) Association between percentage positivity for Bag-1 and p53 in epidermal SCCs. Statistical analysis was performed using a Spearman's ρ-test.