TABLE 4.

Dose titration of PX-6518 against L. donovani in BALB/c mice

Dosing group (1 × s.c.)a	% Body wt gain (day 0-7)b	L. donovani parasite burden in target organc
		Liver amastigote burden		No. of animals with positive:
		Mean ± SD LDU	% Reduction	Spleen	Bone marrow
Placebo	2.7	1,425 ± 131		6	6
PX-6518
5 mg/kg	3.2	0 ± 0	100	6	0
2.5 mg/kg	3.5	0 ± 0	100	6	1
1.25 mg/kg	4.5	2 ± 2	99.9	6	6
0.8 mg/kg	0.4	2 ± 3	99.9	5	6
0.6 mg/kg	7.0	3 ± 1	99.8	6	6
0.4 mg/kg	0.0	69 ± 121	95.2	6	6
0.2 mg/kg	1.3	421 ± 104	70.5	6	6
0.1 mg/kg	2.2	1,102 ± 207	22.7	6	6
Amphotericin (10 mg/kg)	3.7	1,485 ± 152	0	6	6
Stibogluconate (250 mg/kg)	5.1	4 ± 4	99.7	6	6

^aOne day postinfection.

^bMean body weight at start, 22.3 ± 0.56 g (6 animals/experimental group).

^cAutopsy performed at 7 days posttreatment.