TABLE 5.
Five-day residual and curative activity of PX-6518 against L. donovani in BALB/c micea
| Dosing group (1 × s.c.) | Timing (day postinfection) |
L. donovani parasite burden in target organb
|
|||
|---|---|---|---|---|---|
| Liver amastigote burden
|
No. of animals with positive:
|
||||
| Mean ± SD LDU | % Reduction | Spleen | Bone marrow | ||
| Placebo | 1,170 ± 251 | 6 | 6 | ||
| PX-6518 (2.5 mg/kg) | −5 | 0.4 ± 0.6 | 100 | 5 | 4 |
| −3 | 0 ± 0 | 100 | 6 | 3 | |
| −1 | 0 ± 0 | 100 | 6 | 1 | |
| 1 | 0 ± 0 | 100 | 5 | 1 | |
| 3 | 0 ± 0 | 100 | 6 | 5 | |
| 5 | 22 ± 10 | 98.5 | 6 | 5 | |
a
The percent body weight gain was not determined.
b
Autopsy performed at 7 days postinfection.