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. 2011 Apr 5;104(9):1410–1417. doi: 10.1038/bjc.2011.94

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Copyright © 2011 Cancer Research UK

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Inhibition of migration and increased apoptosis of D121 lung carcinoma cells by downregulation of SOX2 gene expression. (A) The expression of SOX2 in D121 lung cancer cells was downregulated by siRNA as verified by western blotting and RT–PCR. (B) Downregulation of TGF-β and Oct 4 while SOX2 expression of SOX2 was knocked down by siRNA. (C) Inhibition of D121 cells migration after downregulation of SOX2. (D–F) Increased apoptosis of D121-SP cells, which was indicated by increasing Caspase-3 and Annexin V after SOX2 knockdown in D121 cells.