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. 2011 Apr 26;7:486. doi: 10.1038/msb.2011.17

Table 1. Hubs in the CNA-driven glioblastoma network model–based on 10 672 genes and 186 patients.

Symbol Amp Del Targets Chrom Pos Description
EGFR 146 2 134 7 55054218 Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
CDKN2B 6 108 46 9 21992905 Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2A 6 108 27 9 21957751 Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
MTAP 6 101 22 9 21792634 Methylthioadenosine phosphorylase
SEC61G 134 2 21 7 54787434 Sec61-gamma subunit
PDGFRA 33 5 19 4 54790203 Platelet-derived growth factor receptor, alpha polypeptide
IFNA1 6 101 14 9 21430439 Interferon-alpha 1
COMMD3 8 130 10 10 22645304 COMM domain containing 3
CHIC2 35 5 9 4 54570714 Cysteine-rich hydrophobic domain 2
GAD2 8 130 9 10 26545599 Glutamate decarboxylase 2 (pancreatic islets and brain, 65 kDa)
IFNA14 6 98 8 9 21191233 Interferon-alpha 14
C10orf97 9 126 6 10 15860180 Chromosome 10 open reading frame 97
MLLT10 9 129 5 10 21863579 Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to 10
PPYR1 12 130 5 10 46503539 Pancreatic polypeptide receptor 1
WIPI2 129 5 5 7 5220425 WD repeat domain, phosphoinositide interacting 2
NDN 1 29 5 15 21481654 Necdin homolog (mouse)
ADARB2 9 123 4 10 1218072 Adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)
ELAVL2 7 91 4 9 23680104 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
GNA12 128 5 4 7 2734268 Guanine nucleotide binding protein (G protein) alpha-12
ARMC4 8 132 3 10 28141104 Armadillo-repeat containing 4
IFNA21 6 96 3 9 21155635 Interferon alpha-21
LANCL2 120 2 3 7 55400634 LanC lantibiotic synthetase component C-like 2 (bacterial)
MAD1L1 129 5 3 7 1821953 MAD1 mitotic arrest deficient-like 1 (yeast)
MGAM 133 7 3 7 141342147 Maltase-glucoamylase (alpha-glucosidase)
MOBKL2B 10 71 3 9 27315207 MOB1, Mps One Binder kinase activator-like 2B (yeast)
ACTR3B 136 1 2 7 152087783 ARP3 actin-related protein 3 homolog B (yeast)
C1GALT1 130 5 2 7 7240413 Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CAMK1D 8 126 2 10 12431588 Calcium/calmodulin-dependent protein kinase ID
CENTA1 129 6 2 7 904065 Centaurin-alpha 1
FBXL18 130 5 2 7 5481953 F-box and leucine-rich repeat protein 18
FTSJ2 128 5 2 7 2240453 FtsJ homolog 2 (E. coli)