TABLE 2.
Activities of pyridines and pyrimidines against C. albicans CAF2-1 and its efflux-negative derivative C. albicans DSY654 and their potency in inducing lanosterol accumulation in C. albicans DSY654
| Compounda | MIC (μg · ml−1) for:
|
IC50, lanosterol (μg · ml−1) for C. albicans DSY654 | |
|---|---|---|---|
| C. albicans CAF2-1 | C. albicans DSY654 | ||
| 2b | >64 | 16 | 1 |
| 3c | >64 | 2 | 0.125 |
| 4c | >64 | 32 | 8 |
| 5a(+) | >64 | 16 | 16 |
| 5a(−) | >64 | 64 | 32 |
| 5b | >64 | 4 | 0.75 |
| 5c | >64 | 64 | 64 |
| 8a | >64 | 2 | 0.25 |
| 8b | >64 | 4 | 0.125 |
| 8c | >64 | 4 | 0.125 |
| 10 | >64 | 8 | 0.125 |
a
For compound 5a, because the absolute configuration of the enantiomerically pure materials was not determined, they are referred to here as the (+) and (−) isomers.