Table 1.
Sample Characteristics
| Study | Thase et al. 200723 (Augment) | Thase et al. 200723 (Substitute) | Scott et al. 200033 | Harley et al. 200828 | Kennedy et al. 200337 | Blackburn and Moore 1997a27 | Wiles et al. 200835 |
|---|---|---|---|---|---|---|---|
| Sample size, n | |||||||
| Psychotherapy | 65 | 36 | 80 | 13 | 23 | 17 | 14 |
| Comparator | 117 | 86 | 78 | 11 | 21 | 20 | 11 |
| Age, y (M ± SD) | |||||||
| Psychotherapy | 40.6 ± 11.5 | 43.4 ± 14.7 | 43.5 ± 9.8 | 41.8 | 40.7 ± 12.5 | 37.8 ± 13.1 | 45.5 ± 12.8 |
| Comparator | 39.7 ± 13.5 | 41.5 ± 13.3 | 43.2 ± 11.2 | 37.7 ± 11.3 | 40.1 ± 12.7 | 45.1 ± 11.1 | |
| Female, n (%) | |||||||
| Psychotherapy | 41 (63%) | 22 (61%) | 37 (46%) | 18 (75%) | 12 (52%) | 17 (77%)a | 12 (85.7%) |
| Comparator | 78 (67%) | 53 (62%) | 41 (53%) | 12 (57%) | 17 (65%)a | 9 (81.8%) | |
| Caucasian, n (%) | |||||||
| Psychotherapy | 52 (80%) | 28 (78%) | _ | 20 (83%) | _ | _ | _ |
| Comparator | 99 (85%) | 63 (73%) | |||||
| Duration of current episode, wks (M±SD) | |||||||
| Psychotherapy | 129 ± 214 | 76 ± 135 | 62.9 | 28.7 ± 18.8 | 126 ± 170 | 30.4 ± 6.1 | 86% > 1 yr |
| Comparator | 87 ± 206 | 115 ± 234 | 56.4 | 41.8 ± 53.6 | 120 ± 161 | 29.9 ± 5.6 | 82% > 1 yr |
| Number of prior MDD episodes (M ± SD) | |||||||
| Psychotherapy | 7.3 ± 14.1 | 8.7 ± 18.8 | 2 (median) | Not reported | 2.1 ± 1.5 | 4.1 ± 3.4 | Not reported |
| Comparator | 4.6 ± 5.4 | 8.4 ± 16.0 | 2 (median) | 2.3 ± 1.4 | 3.2 ± 2.2 | ||
| Baseline HAM-Db scores | |||||||
| Psychotherapy | 17.8 ± 5.7 | 16.4 ± 6.2 | 12.1 ± 2.7 | 16.2 ± 4.5 | 12.1 ± 2.2 | 11.8 ± 6.3 | Not administered |
| Comparator | 16.0 ± 6.7 | 16.0 ± 6.7 | 12.2 ± 2.9 | 18.6 ± 4.7 | 11.6 ± 1.9 | 10.6 ± 6.8 | |
| Baseline self-report scores | QIDS-SRd | QIDS-SR | BDIc | BDI | BDI | BDI | BDI |
| Psychotherapy | 11.9 ± 4.3 | 11.2 ± 4.3 | 21.7 ± 7.7 | 27.3 ± 8.8 | 22.7 ± 8.6 | 20.4 ± 11.1 | 31.1 ± 8.5 |
| Comparator | 12.0 ± 4.6 | 12.1 ± 4.6 | 22.3 ± 8.0 | 27.4 ± 11.7 | 22.4 ± 10.3 | 19.7 ± 14.2 | 26.8 ± 6.8 |
| Setting | MHC & PCf | MHC & PC | MHCe | MHC | MHC | MHC | PC |
| Location | U.S.A. | U.S.A. | England | U.S.A. | Canada | Scotland | England |
aHAM-D, BDI and QIDS-SR scores for this study based on smaller number that enrolled in phase 2 of the study following initial treatment with antidepressants; bHAM-D = Hamilton Depression Scale; cBDI = Beck Depression Inventory; dQIDS-SR = Quick Inventory of Depressive Symptoms-Self Report; eMHC = Mental Health Clinic; fPC = Primary Care Clinic