FIG. 1.

Effect of subcutaneous antibiotic administration on persistence and density of VRE in the stool of mice. All mice were colonized with VRE on day 0 (mean, 9 log₁₀CFU/g of stool). Subcutaneous antibiotics (eight mice per group) were administered every 12 h from day 0 to day 15. Densities of VRE are shown for low-dose antibiotics (equal to human doses on a milligram-per-kilogram basis) (A), medium-dose antibiotics (five times the low dose) (B), and corrected human-equivalent doses of antibiotics (C). If VRE was not detected in stool, the lower limit of detection (∼2 log₁₀CFU/g) was assigned. ▵, normal saline; ○, levofloxacin; •, gatifloxacin; □, moxifloxacin; ▴, ciprofloxacin; ▪, clindamycin.