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. 2011 Mar 29;30(9):1753–1765. doi: 10.1038/emboj.2011.95

Figure 8.

Figure 8

Regulation of TSC22 family members in OIS. Our results suggest a model in which TSC22D1.1 and THG1 form heterodimers in proliferating HDF or melanocytes. Upon BRAFE600 expression, TSC22D1.2 variants are strongly induced and compete with TSC22D1.1 (whose levels decline by proteasomal degradation) for binding to THG1, resulting in displacement of the latter and induction of OIS. OIS can be abrogated by the downregulation of TSC22D1.2 or the ectopic expression of either THG1 or TSC22D1.1. The latter interacts with THG1, allowing for OIS abrogation. Since TSC22D1.1 levels are very low in OIS, exogenous THG1 abrogates cell-cycle arrest most likely through homodimerization.