TABLE 1.
PAEs against M. tuberculosis H37Rv (ATCC 27294) after a 2-h exposure to single drugs and combinations of drugs
| Drug(s) (concn [mg/liter]) | Drug concn/MIC | PAE (h)a | CV (%)b |
|---|---|---|---|
| Rifapentine (20) | 160 | 104.0 (88.6-121.9) | 16 |
| Rifapentine (10) | 80 | 75.3 (5.6-154.8) | 95 |
| Isoniazid (2) | 33.3 | 19.7 (6.0-23.0) | 55 |
| Moxifloxacin (2) | 8 | 0.3 (0.0-18.5) | 169 |
| Moxifloxacin (1) | 4 | 0 (0) | |
| Rifapentine (10) + isoniazid (2) | 80 + 33.3 | 136.5 (40.7-260.5) | 76 |
| Rifapentine (10) + moxifloxacin (1) | 80 + 4 | 59.0 (32.7-64.7) | 33 |
| Isoniazid (2) + moxifloxacin (1) | 33.3 + 4 | 8.3 (0-27.7) | 118 |
a
Values are medians, and their ranges are in brackets.
b
CV, coefficient of variation.