Table 1. Genotype and allele frequency comparison of XRCC1 (c.1316G>A [rs25487]) in controls and patients and with gender distribution.
| Genotype | Male+Female Controls (n=193) | Male+Female POAG (n=160) | p (z) | p (χ2) | OR (95% CI) | Male+Female PCAG (n=163) | p (z) | p (χ2) | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| GG |
98(51%) |
70(44%) |
>0.05(1.32) |
>0.05 (5.69) |
DM=1.33(0.87–2.02) p>0.05 RM=0.65(0.35–1.21) p>0.05 |
79(48%) |
>0.05(0.43) |
>0.05(0.25) |
DM=1.1(0.72–1.66) p>0.05 RM=1.13(0.64–1.97) p>0.05 |
| GA |
65(34%) |
73(46%) |
<0.05(2.29) |
|
|
56(34%) |
>0.05(0.13) |
|
|
| AA |
30(15%) |
17(10%) |
>0.05 (1.35) |
|
|
28(17%) |
>0.05(0.42) |
|
|
|
Allele |
Male+Female Controls |
Male+Female POAG |
p (χ2) |
OR (95% CI) |
Male+Female PCAG |
p (χ2) |
OR (95% CI) |
|
|
| G |
261(68%) |
213(67%) |
>0.05(0.09) |
1.05(0.77–1.44) p>0.05 |
214(66%) |
>0.05(0.31) |
1.09(0.8–1.49) |
|
|
| A |
125(32%) |
107(33%) |
|
|
112(34%) |
|
p>0.05 |
|
|
|
Genotype |
Male Controls (n=101) |
Male POAG (n=80) |
p (z) |
p (χ2) |
OR (95% CI) |
Male PCAG (n=81) |
p (z) |
p (χ2) |
OR (95% CI) |
| GG |
58(57%) |
27(34%) |
<0.005(3.17) |
0.001(13.2) |
DM=2.65(1.44–4.85) p<0.005 RM=0.82(0.35–1.91) p>0.05 |
38(47%) |
>0.05(1.41) |
>0.05(2.05) |
DM=1.53(0.85–2.74) p>0.05 RM=1.2(0.55–2.62) p>0.05 |
| GA |
28(28%) |
43(54%) |
<0.001(3.56) |
|
|
29(36%) |
>0.05(1.17) |
|
|
| AA |
15(15%) |
10(12%) |
>0.05(0.46) |
|
|
14(17%) |
>0.05(0.45) |
|
|
|
Allele |
Male Controls |
Male POAG |
p (χ2) |
OR (95% CI) |
Male PCAG |
p (χ2) |
OR (95% CI) |
|
|
| G |
144(71%) |
97(61%) |
<0.05(4.56) |
1.61(1.04–2.5) p<0.05 |
105(65%) |
>0.05(1.33) |
1.3(0.83–2.03) p>0.05 |
|
|
| A |
58(29%) |
63(39%) |
|
|
55(35%) |
|
|
|
|
|
Genotype |
Female Controls (n=92) |
Female POAG (n=80) |
p (z) |
p (χ2) |
OR (95% CI) |
Female PCAG (n=82) |
p (z) |
p (χ2) |
OR (95% CI) |
| GG |
40(44%) |
43(54%) |
>0.05(1.34) |
>0.05(2.93) |
DM=0.66(0.36–1.21) p>0.05 RM=0.49(0.2–1.25) p>0.05 |
41(50%) |
>0.05(0.86) |
>0.05(1.04) |
DM=0.77(0.42–1.4) p>0.05 RM=1.06(0.48–2.32) p>0.05 |
| GA |
37(40%) |
30(37%) |
>0.05(0.36) |
|
|
27(33%) |
>0.05(1.0) |
|
|
| AA |
15(16%) |
7(9%) |
>0.05(1.48) |
|
|
14(17%) |
>0.05(0.14) |
|
|
|
Allele |
Female Controls |
Female POAG |
p (χ2) |
OR (95% CI) |
Female PCAG |
p (χ2) |
OR (95% CI) |
|
|
| G |
117(64%) |
116(72%) |
>0.05(3.11) |
0.66(0.42–1.05) p>0.05 |
109(66%) |
>0.05(0.32) |
0.88(0.57–1.37) p>0.05 |
|
|
| A | 67(36%) | 44(28%) | 55(34%) |
DM=dominant model, RM=recessive model. Significant p values (<0.05) are in bold italics.