Table 2. Genotype and allele frequency comparison of XPD (c.2298A>C [rs13181]) in controls and patients and with gender distribution.
| Genotype | Male+Female Controls (n=193) | Male+Female POAG (n=160) | p (z) | p (χ2) | OR (95% CI) | Male+Female PCAG (n=163) | p (z) | p (χ2) | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| AA |
92(48%) |
52(33%) |
<0.005(2.89) |
0.01(8.75) |
DM=1.89(1.23–2.92) p=0.005 RM=1.62(0.91–2.86) p>0.05 |
58(36%) |
<0.05(2.3) |
>0.05 (5.68) |
DM=1.65(1.08–2.53) p<0.05 RM=1.52(0.86–2.69) p>0.05 |
| AC |
76(39%) |
77(48%) |
>0.05(1.65) |
|
|
75(46%) |
>0.05(1.26) |
|
|
| CC |
25(13%) |
31(19%) |
>0.05(1.64) |
|
|
30(18%) |
>0.05(1.42) |
|
|
|
Allele |
Male+Female Controls |
Male+Female POAG |
p (χ2) |
OR (95% CI) |
Male+Female PCAG |
p (χ2) |
OR (95% CI) |
|
|
| A |
260(55%) |
181(57%) |
<0.005(8.7) |
1.59(1.17–2.15) p<0.005 |
191(59%) |
|
1.46(1.07–1.98) p<0.05 |
|
|
| C |
126(33%) |
139(43%) |
|
|
135(41%) |
<0.05(5.85) |
|
|
|
|
Genotype |
Male Controls (n=101) |
Male POAG (n=80) |
p (z) |
p (χ2) |
OR (95% CI) |
Male PCAG (n=81) |
p (z) |
p (χ2) |
OR (95% CI) |
| AA |
56(55%) |
27(34%) |
<0.005(2.91) |
<0.005(12.1) |
DM=2.44(1.33–4.47) p<0.005 RM=3.62(1.45–9.01) p<0.01 |
33(41%) |
0.05(1.97) |
>0.05 (4.71) |
DM=1.81(1.00–3.26) p=0.05 RM=2.1(0.8–5.55) p>0.05 |
| AC |
38(38%) |
36(45%) |
>0.05(1.00) |
|
|
37(46%) |
>0.05(1.1) |
|
|
| CC |
7(7%) |
17(21%) |
0.005(2.82) |
|
|
11(13%) |
>0.05(1.49) |
|
|
|
Allele |
Male Controls |
Male POAG |
p (χ2) |
OR (95% CI) |
Male PCAG |
p (χ2) |
OR (95% CI) |
|
|
| A |
150(74%) |
90(56%) |
<0.001(12.96) |
2.24(1.44–3.49) p<0.001 |
103(64%) |
<0.05(4.84) |
1.65(1.06–2.6) p<0.05 |
|
|
| C |
52(26%) |
70(44%) |
|
|
59(36%) |
|
|
|
|
|
Genotype |
Female Controls (n=92) |
Female POAG (n=80) |
p (z) |
p (χ2) |
OR (95% CI) |
Female PCAG (n=82) |
p (z) |
p (χ2) |
OR (95% CI) |
| AA |
36(39%) |
25(31%) |
>0.05(1.08) |
>0.05(1.77) |
DM=1.41(0.76–2.65) p>0.05 RM=0.87(0.41–1.87) p>0.05 |
25(31%) |
>0.05(1.19) |
>0.05 (1.44) |
DM=1.47(0.78–2.74) p>0.05 RM=1.2(0.6–2.55) p>0.05 |
| AC |
38(41%) |
41(51%) |
>0.05(1.31) |
|
|
38(46%) |
>0.05(0.67) |
|
|
| CC |
18(20%) |
14(18%) |
>0.05(0.35) |
|
|
19(23%) |
>0.05(0.58) |
|
|
|
Allele |
Female Controls |
Female POAG |
p (χ2) |
OR (95% CI) |
Female PCAG |
p (χ2) |
OR (95% CI) |
|
|
| A |
110(60%) |
91(57%) |
>0.05(0.3) |
1.13(0.73–1.73) p>0.05 |
88(54%) |
>0.05(1.33) |
1.3(0.84–1.96) p>0.05 |
|
|
| C | 74(40%) | 69(43%) | 76(46%) |
DM=dominant model, RM=recessive model. Significant p values (<0.05) are in bold italics.