Table 3. XPD and XRCC1 combined genotype comparison of controls and patients.
| XPD/ XRCC | Male+Female Controls (n=193) | Male+Female POAG (n=160) | p (χ2) | p (z) | Male+Female PCAG (n=163) | p (χ2) | p (z) |
|---|---|---|---|---|---|---|---|
| AA/GG |
48(25%) |
25(15%) |
0.01 (20.44) |
<0.05(2.14) |
31(19%) |
>0.05 (7.18) |
>0.05(1.32) |
| AA/GA |
30(16%) |
19(12%) |
>0.05(0.99) |
18(11%) |
>0.05(1.24) |
||
| AA/AA |
14(7%) |
8(5%) |
>0.05(0.87) |
9(5%) |
>0.05(0.66) |
||
| AC/GG |
40(21%) |
29(18%) |
>0.05(0.61) |
35(21%) |
>0.05(1.72) |
||
| AC/GA |
26(13%) |
45(28%) |
<0.001(3.42) |
26(16%) |
>0.05(0.66) |
||
| AC/AA |
10(5%) |
3(2%) |
>0.05(1.64) |
14(9%) |
>0.05(1.28) |
||
| CC/GG |
10(5%) |
16(10%) |
>0.05(1.73) |
13(8%) |
>0.05(1.07) |
||
| CC/GA |
9(4%) |
9(6%) |
>0.05(0.41) |
12(7%) |
>0.05(1.08) |
||
| CC/AA |
6(3%) |
6(4%) |
>0.05(0.33) |
5(3%) |
>0.05(0.02) |
||
|
XPD/ XRCC |
Male Controls (n=101) |
Male POAG (n=80) |
p (χ2) |
p (z) |
Male PCAG (n=81) |
p (χ2) |
p (z) |
| AA/GG |
36(35%) |
12(15%) |
<0.001 (27.04) |
<0.001(3.12) |
17(21%) |
>0.05 (9.60) |
<0.05(2.16) |
| AA/GA |
11(11%) |
12(15%) |
>0.05(0.82) |
11(14%) |
>0.05(0.55) |
||
| AA/AA |
9(9%) |
3(4%) |
>0.05(1.39) |
5(6%) |
>0.05(0.69) |
||
| AC/GG |
20(20%) |
9(11%) |
>0.05(1.56) |
17(21%) |
>0.05(0.20) |
||
| AC/GA |
14(14%) |
26(33%) |
<0.001(3.00) |
12(15%) |
>0.05(0.18) |
||
| AC/AA |
4(4%) |
1(1%) |
>0.05(1.10) |
8(10%) |
>0.05(1.60) |
||
| CC/GG |
2(2%) |
6(7%) |
>0.05(1.79) |
4(5%) |
>0.05(1.11) |
||
| CC/GA |
3(3%) |
5(6%) |
>0.05(1.07) |
6(7%) |
>0.05(1.37) |
||
| CC/AA |
2(2%) |
6(7%) |
>0.05(1.79) |
1(1%) |
>0.05(0.39) |
||
|
XPD/ XRCC |
Female Controls (n=92) |
Female POAG (n=80) |
p (χ2) |
p (z) |
Female PCAG (n=82) |
p (χ2) |
p (z) |
| AA/GG |
12(13%) |
13(16%) |
>0.05 (13.01) |
>0.05(0.60) |
14(17%) |
>0.05 (5.57) |
>0.05(0.74) |
| AA/GA |
19(21%) |
7(9%) |
<0.05(2.17) |
7(8%) |
<0.05(2.24) |
||
| AA/AA |
5(5%) |
5(6%) |
>0.05(0.23) |
4(5%) |
>0.05(0.17) |
||
| AC/GG |
20(22%) |
20(25%) |
>0.05(0.50) |
18(22%) |
>0.05(0.03) |
||
| AC/GA |
12(13%) |
19(24%) |
>0.05(1.82) |
14(17%) |
>0.05(0.74) |
||
| AC/AA |
6(6%) |
2(3%) |
>0.05(1.25) |
6(7%) |
>0.05(0.21) |
||
| CC/GG |
8(9%) |
10(12%) |
>0.05(0.81) |
9(11%) |
>0.05(0.51) |
||
| CC/GA |
6(6%) |
4(5%) |
>0.05(0.43) |
6(7%) |
>0.05(0.21) |
||
| CC/AA | 4(4%) | 0(0%) | >0.05(1.89) | 4(5%) | >0.05(0.17) |
Significant p values (<0.05) are in bold italics.