FIG. 2.

Lesion growth in mice treated with meglumine antimoniate (MA) or its complex with β-cyclodextrin (MA/CD). The mice were infected in the ear with L. amazonensis-GFP and then treated daily with meglumine antimoniate-β-cyclodextrin compound (32 mg of Sb/kg) or meglumine antimoniate (120 mg of Sb/kg) on days 10 to 16 and 31 to 36 of infection. The controls received saline or meglumine antimoniate (60 mg of Sb/kg) by the i.p. route. The ear thickness was measured on the indicated days and expressed as means ± standard deviations (n = 5).