Clinical manifestations and complications |
Increased susceptibility to bacterial infections, especially encapsulated organisms and opportunistic viral and fungal infections; autoimmune diseases, such as myasthenia gravis, neutropenia, pure red blood cell aplasia, and anemia |
Laboratory findings |
Hypogammaglobulinemia, low to absent levels of B cells, CD4+ T lymphopenia, reduced T-cell mitogen proliferation response |
Treatment options |
Resection of thymoma if malignant, invasive, or obstructive; immunoglobulin replacement; antibiotics if indicated; immunosuppressive agents if associated with autoimmune disease |