Figure 7. L-NNA treatment is comparable to cisplatin.
L-NNA with IR is seen to be as, or more, effective than any other treatment in A431 xenografts. Flank xenograft tripling time following the treatments indicated (A). Data presented as mean ± SEM. Median survival times of animals bearing flank xenografts following the treatments indicated (B). Significance calculated by log-rank analysis. Cisplatin delivered as a single i.p. bolus at 8 mg/kg on day 0; L-NNA provided from day 0 at 0.5 g/L in drinking water; irradiated animals received a single 10 Gy dose targeted at the flank using a 60Co source on day 1. (* = p<0.05, ** = p<0.02, *** = p<0.01).