TABLE 1.

Effects of COX inhibitors on biofilm formation by three strains of C. albicans

Inhibitor	XTT reduction (%)a by biofilms after 48 h
	Strain GDH 2346	Strain SC5314	Strain CAI4
Aspirin	20.6 ± 2.8b	12.3 ± 2.2b	4.6 ± 0.8b
Diclofenac	57.6 ± 3.6b	31.2 ± 1.1b	59.7 ± 2.6b
Ibuprofen	82.7 ± 3.9c	81.7 ± 6.3c	88.4 ± 6.3d
Indomethacin	92.7 ± 2.8	95.8 ± 4.2	85.7 ± 13.8
Piroxicam	93.7 ± 2.9	84.4 ± 6.0	80.6 ± 7.4
Celecoxibe	77.3 ± 2.7b	79.5 ± 7.4c	94.0 ± 3.9
Etodolace	62.9 ± 1.5b	49.4 ± 3.8b	73.4 ± 3.6b
Meloxicame	88.4 ± 7.0d	84.5 ± 3.0b	81.3 ± 2.4b
Nimesulidee	84.8 ± 3.5c	86.7 ± 7.8d	94.4 ± 6.3

^aInhibitors were present during the adhesion period and throughout the 48-h growth period. XTT reduction is expressed as a percentage of that of control biofilms of the same strain incubated in the absence of inhibitor. The results are means ± standard errors of the means of at least two independent experiments carried out in triplicate. Mean ± standard error of the mean values (A₄₉₂) for the controls were 2.413 ± 0.069, 2.676 ± 0.066, and 2.833 ± 0.072 for strains GDH 2346, SC5314, and CAI4, respectively.

^bValue significantly different at P < 0.001 from that for the control.

^cValue significantly different at P < 0.01 from that for the control.

^dValue significantly different at P < 0.05 from that for the control.

^eCOX-2 inhibitor.