Table 3. Univariate and multivariate analyses of different genotypes and RP (grade≥1) for NSCLC (N = 196).

Genotypes	Patient No.	Event	Crude		P *	Adjusted		P †
			HR	95% CI		HR	95% CI
RAD51
(rs1801320 −135G>C)
GG	156	115	1.00			1.00
CG	34	18	0.55	0.34–0.91	0.020	0.50	0.29–0.84	0.009
CC	5	3	0.60	0.15–2.44	0.477	0.80	0.19–3.37	0.764
CG+CC	39	21	0.56	0.35–0.90	0.017	0.52	0.31–0.86	0.010
RAD51
(rs1801321 −172G>T)
TT	125	89	1.00			1.00
TG	71	48	0.82	0.58–1.17	0.279	0. 730	0.50–1.08	0.117
GG	0	0	N/A			N/A
TG+GG	71	48	0.82	0.58–1.17	0.279	0. 730	0.50–1.08	0.117
XRCC2
(rs3218384 4234G>C)
GG	120	85	1.00			1.00
GC	66	47	1.03	0.72–1.47	0.870	1.21	0.81–1.80	0.361
CC	10	5	0.86	0.35–2.13	0.748	0.90	0.35–2.32	0. 830
GC+CC	76	52	1.01	0.72–1.43	0.949	1.17	0.79–1.73	0.437
XRCC2
(rs3218536 G>A R188H)
GG	173	126	1.00			1.00
AG	16	8	0.56	0.27–1.14	0.107	0.55	0.25–1.19	0.129
AA	0	0	N/A			N/A
AG+AA	16	8	0.56	0.27–1.14	0.107	0.55	0.25–1.19	0.129
XRCC3
(rs861539 C>T T241M)
CC	58	43	1.00			1.00
CT	81	59	0.90	0.61–1.33	0.591	0.92	0.60–1.40	0.690
TT	57	35	0.70	0.45–1.09	0.119	0.63	0.38–1.04	0.069
CT+TT	138	94	0.81	0.57–1.17	0.263	0.80	0.54–1.19	0.271
NBN
(rs1805794 E185Q)
CC	93	68	1.00			1.00
CG	85	57	0.98	0.69–1.39	0.909	1.09	0.75–1.60	0.651
GG	16	11	1.12	0.59–2.13	0.722	1.09	0.54–2.19	0.805
CG+GG	101	68	1.00	0.71–1.40	1.000	1.10	0.76–1.58	0.629

*P values were calculated by Cox proportional model using univariate analysis.

^† P values were calculated with adjustment for age, sex, smoking status, tumor histology, KPS score, tumor stage, application of chemotherapy and mean lung dose.