Table 1.
Highest differentially upregulated genes: no treatment, carboplatin-resistant (CarboR) versus parental
| Gene name | Description | GenBank accession | Expression ratio (CarboR/Parental) | Adjusted P Value |
|---|---|---|---|---|
| HCLS1 | Hematopoietic cell-specific Lyn substrate 1 | NM_005335 | 62.4 | 1.72E-16 |
| UNQ2541 | MSFL2541 | NM_203347 | 33.5 | 5.23E-13 |
| KLHL1 | Kelch-like 1 (Drosophila) | NM_020866 | 21.6 | 2.06E-10 |
| SEPT1 | Septin 1 | NM_052838 | 18.4 | 6.34E-12 |
| FUT3 | Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) | NM_000149 | 13.3 | 1.10E-10 |
| TPM4 | Tropomyosin 4 | NM_003290 | 12.8 | 1.26E-13 |
| ANG | Angiogenin, ribonuclease, RNase A family, 5 | NM_001145 | 12.3 | 9.98E-08 |
| RNASE4 | Ribonuclease, RNase A family, 4 | NM_194430 | 11.2 | 9.89E-08 |
| CLCA1 | Chloride channel, calcium activated, family member 1 | NM_001285 | 9.8 | 4.06E-06 |
| LOC199725 | Hypothetical protein LOC199725 | XM_086001 | 9.4 | 2.11E-05 |
| PNMA3 | Paraneoplastic antigen MA3 | NM_013364 | 9.1 | 1.34E-11 |
| VCX3A | Variable charge, X-linked 3A | NM_016379 | 9.0 | 1.64E-06 |
| PNMA5 | Paraneoplastic antigen like 5 | NM_052926 | 8.7 | 5.35E-13 |
| LOC340061 | Hypothetical protein LOC340061 | NM_198282 | 8.6 | 3.86E-07 |
| SUCNR1 | Succinate receptor 1 | NM_033050 | 8.5 | 8.00E-08 |
| VCX | Variable charge, X-linked | NM_013452 | 8.3 | 1.84E-05 |
| VCX2 | Variable charge, X-linked 2 | NM_016378 | 8.2 | 1.29E-06 |
| PNMA6A | Paraneoplastic antigen like 6A | NM_032882 | 8.1 | 1.57E-06 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | NM_145032 | 8.1 | 1.20E-08 |
| VCY | Variable charge, Y-linked | NM_004679 | 8.0 | 5.85E-09 |
| VCX2 | Variable charge, X-linked 2 | NM_016378 | 8.0 | 5.98E-08 |
| TMEM71 | Transmembrane protein 71 | NM_144649 | 7.8 | 4.59E-09 |
| STMN2 | Stathmin-like 2 | NM_007029 | 7.4 | 1.00E-06 |
| HOXB9 | Homeobox B9 | NM_024017 | 7.3 | 2.09E-12 |
| ZNF179 | Zinc finger protein 179 | NM_007148 | 7.0 | 1.02E-10 |
| TSPAN1 | Tetraspanin 1 | NM_005727 | 6.7 | 2.68E-09 |
| FER1L3 | Fer-1-like 3, myoferlin (C. elegans) | NM_013451 | 6.6 | 1.13E-07 |
| SEZ6 | Seizure related 6 homolog (mouse) | NM_178860 | 6.2 | 0.000643 |
| COL8A1 | Collagen, type VIII, alpha 1 | NM_001850 | 6.0 | 1.74E-05 |
| FER1L3 | Fer-1-like 3, myoferlin (C. elegans) | NM_013451 | 5.9 | 4.15E-08 |
| ANXA3 | Annexin A3 | NM_005139 | 5.9 | 3.19E-08 |
| LECT1 | Leukocyte cell derived chemotaxin 1 | NM_007015 | 5.8 | 0.000185 |
| SHC2 | SHC (Src homology 2 domain containing) transforming protein 2 (SHC2) | XM_939572 (NM_012435) | 5.8 | 0.001418 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | NM_001175 | 5.7 | 0.002958 |
| PRSS16 | Protease, serine, 16 (thymus) | NM_005865 | 5.7 | 1.33E-06 |
| BRDG1 | BCR downstream signaling 1 | NM_012108 | 5.5 | 0.001209 |
| HOXC9 | Homeobox C9 | NM_006897 | 5.3 | 6.11E-12 |
| FST | Follistatin | NM_013409 | 5.1 | 0.002365 |
| HGD | Homogentisate 1,2-dioxygenase (homogentisate oxidase) | NM_000187 | 5.0 | 2.08E-05 |
Adjusted p value <0.01, greater than fivefold differential expression