Table 2.

Functional annotation cluster analysis: no treatment, carboplatin-resistant versus parental

Functional group		Category	Fold enrichment	Genes	P Value
1	Homeobox; Homeodomain related	U, I, S, SP	4.9–6.4	LBX1, ARX, DLX1, DLX2, DLX4, TLX2, HOXA7, HOXA9, HOXA13, HOXB2, HOXB5, HOXB6, HOXB7, HOXB8, HOXB9, HOXC9, SIX6, PAX3	1.4E-7 to 2.3E-9 Median: 8.4E-8
2	Acyltransferase activity; glutathione biosynthetic process	SP, GM, I, GB, K	1.6–37.4	GGT1, GGT3, GSTT1, GGTL4, GGTLA4, GLYATL1	1.1E-4 to 3.9E-1 Median: 6.3E-3
3	Tumor associated protein MAGE	U, I, P	7.3–7.8	MAGEA8, MAGEA9, MAGEA11, MAGEB2	1.5E-2 to 5.5E-2 Median: 1.7E-2
4	Cadherin; Homophilic cell adhesion	GB, I, U, S	3.0–4.5	CDH3, PCDH8, PCDH12, PCDHB8, PCDHB16, CLSTN2, FRAS1	2.5E-2 to 1.0E-1 Median: 4.6E-2
5	Regulation of phosphorylation	GB	1.8–3.9	ANG, HCLS1, IGFBP3, SYK, TNF	4.6E-2 to 4.8E-1 Median: 8.1E-2

Fold upregulated >2, adjusted p value <0.05

Annotation database/category abbreviations: U UP seq feature, I interpro, S smart, SP SP PIR keywords, GM GOTerm MF ALL, GB GOTerm BP ALL, P PIR superfamily, K KEGG pathway