Figure 2.

Volume-of-interest dihydrotetrabenazine (DTBZ) binding in the putamen. DVR values for the lowest hemisphere of each subject are depicted according to the qualitative image-based subject classification. A cut-off value of 2.51 is depicted by the horizontal line, representing −2.5 SD below the mean of the subjects with Alzheimer’s disease (AD). Based on the assumption that subjects with frontotemporal dementia (FTD) may have mild dihydrotetrabenazine reduction, there may be one subject with Lewy body dementia (DLB) and one subject with FTD that could be reclassified on the basis of volume of interest quantification compared with the qualitative visual analysis (see text for detailed discussion).