Table 2.
Cancer-specific methylated genes and their proposed functions
| Genes | Loci | Gene name | Proposed function |
|---|---|---|---|
| NISCH | 3p21.1 | Nischarin | Human I(l)-imidazdine receptor candidate gene, IRAS |
| PIGH | 14q11-q24 | Phosphatidylinositol glycan, class H cyclin-dependent kinase inhibitor 1A (p21, Cip1) activated | Encodes an endoplasmic reticulum associated–protein that is invovled in GPI-anchor biosynthesis |
| PAK3 | Xq22.3-q23 | Kinase 3 | Critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling |
| TUBB4 | 19p13.3 | Tubulin, β4 | β-tubulin |
| KIF1A | 2q37.3 | Kineasin family member 1A | Anterograde motor protein that transports membranous organelles along axonal microtubules |
| MAL | 2cen-q13 | T-cell proliferation protein | A candidate linker protein in T-cell signal transduction |
| ENPEP | 4q25 | Glutamyl aminpeptidase | Type II integral membrane protein |
| MCAM | 11q23.3 | Melanoma cell adhasion molecule | Cell adhesion |
| SSBP2 | 5q13.3 | ssDNA-binding protein 2 | DNA binding |
| B4GALT1 | 9p21 | β 1,4-galactosyltransferase, polypeptide 1 | Elevated level in highly metastatic human lung cancer cells |
| OSMR | 5p12 | Oncostatin M receptor | Induces apoptosis in adrenocortical Y-1 tumor cells |
| NTRK2 | 9q22.1 | Neurotrophic tyrosine kinase, receptor, type 2 | Receptor for brain-derived neurotrophic factor, neurotrophin-3 |
| PAPSS2 | 10q23.1-q23.2 | 3′-phosphoadenosis 5′-phosphosulfate synthetase 2 | Bifunctional enzyme with both atp sulfurylase and aps kinase activity |
| SFRP4 | 7p14.1 | Secreted frizzled-related protein 4 | Modulators of Wnt signaling |
| TUBG2 | 17q21 | γ-Tubulin gene | Ostomalacia-associated tumors and endometrial and breast carcinomas |
| PTGS 2 | 1q25.2-q25.3 | Prostaglandin-endoperoxide synthase 2 | Prostaglandin biosynthesis |
| NPTX1 | 17q25.1-q25.2 | Neuronal pentraxin I | Calcium ion binding, transport, and synaptic transmission |
| CCNA1 | 13q12.3-q13 | Cyclin A1 | Cell cycle |
| ASMTL | Xp22.3; Yp11.3 | Acetylserotonin O-methyltransferase like | O-methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity |
| TFP12 | 7q22 | Tissue factor pathway inhibitor 2 | Serine-type endopeptidase inhibitor activity, extracellular matrix structural constituent |
| OGDHL | 10q11.23 | Oxoglutarate dehydrogenase like | Plays a major role in the citric acid cycle, converting α-ketoglutarate to succiynl CoA |
| DLL4 | 15q14 | Δ-like 4 (Drosophila) | Notch binding, calciumion binding |
| GDAP1L1 | 20q12 | Ganglioside-induced differentiation-associated protein 1-like 1 | Mutation in human GDAP1 are associated with Charcot-Marie-Tooth–type 4A disease |
| C1ORF166 | 1p36.12 | Hypothetical protein LOC79594 | Involved in mediating protein-protein interactions |
| ARMC7 | 17q25.1 | Amadillo repeat containing 7 | Binding |
| C13orf18 | 13q14.12 | Protein chromosome 13 open reading frame 18 | Protein phosphatase inhibitor activity |
| C9orf19 | 9p13-p12 | Golgi-associated plant pathogenesis-related protein 1 | Extracellular region |
| HCP1 | 17q11.2 | Home carrier protein 1 | Transporter activity |