Fig. 1.
β-cell-specific deletion of Xbp1 causes hyperglycemia and glucose intolerance in mice. (A) Blood glucose and (B) serum insulin levels were measured after fasting mice for 6 h. Each dot represents an individual male mouse (7-wk-old). (C) Fed-state blood glucose levels of WT and β-cell-specific Xbp1 knockout (Xbp1f/f;RIP-cre) mice were measured along the time course. n = 6–8 male mice per group. Values represent means ± SEM. (D) GTTs were performed on 7- to 8-wk-old mice. n = 6–8 mice per group. (E) ITT was performed on 16-wk-old male mice. n = 5–7 mice per group. *P < 0.05; ***P < 0.001.