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. 2011 May 9;108(21):8873–8878. doi: 10.1073/pnas.1101567108

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Fig. 4. — Relationship between functional and structural measures of integrity. (A) We found a negative relationship between the left DG/CA3 slope of activity in older adults and fractional anisotropy in this region (an indication of dendritic integrity), providing evidence that intact synaptic function in this region is necessary for successful pattern separation. (B) We found a negative relationship between the left DG/CA3 slope of activity in older adults and their perforant path integrity, suggesting that degradation in this pathway may underlie the network's representational rigidity. (C) We also found a positive relationship between perforant path integrity in older adults and their separation bias on the explicit recognition task, providing further evidence that the perforant path is necessary for successful discrimination. (D) We found a negative relationship between the left DG/CA3 slope of activity in older adults and degree of functional coupling between the left entorhinal cortex and the left DG/CA3 suggesting that communication failure in this network is linked to the representational rigidity observed.