Fig. 7.

Pax2 regulates some VR/OS genes in parallel to RAR signaling. (A and B) Lateral views of 25- to 26-hpf eyes. Approximately 15–20 control or mutant embryos for each probe were used for these analyses. (A) The noi embryos show down-regulation of net1a, cyb5a, and itgA5, but not vax1, in the VR/OS (arrowheads). Arrows point to itgA5 expression in extraocular tissue at the back of the eye. (B) Expression of dact1, nlz2, dhrs3a, and rdh10a in ventral eye cells is not affected in the noi mutants (arrowheads). Triangles point to nlz2 dorsal retinal expression. (C) Proposed model of the molecular mechanisms of RAR signaling in the developing zebrafish VR/OS (highlighted in gray). See text for details.