Table II.
Genotypic and allelic distribution at serotonin transporter loci
| Genotype frequency | Allele frequency | |||||
|---|---|---|---|---|---|---|
| Controls (n=92) | OCD cases (n=93) | Controls (n=184) | OCD cases (n=186) | |||
| Genotypic and allelic distribution at 5-HTTVNTR: | ||||||
| 10 10 | 12 (0.103) | 11 (0.118) | 10 | 55 (0.298) | 52 (0.279) | |
| 10 12 | 31 (0.336) | 30 (0.322) | 12 | 129 (0.701) | 134 (0.720) | |
| 12 12 | 49 (0.532) | 52 (0.559) | ||||
| Chi square=0.14 df=2 P=0.93 | Chi square=.09 df=1 P=0.76 Genotypic | |||||
| Genotypic and allelic distribution of 5-HTTLPR (L/S) polymorphism and rs25531(A/G): | ||||||
| LA LA | 4 (0.04) | 8 (0.08) | LA | 47 (0.25) | 53 (0.28) | |
| LA LG | 6 (0.06) | 7 (0.07) | LG | 25 (0.13) | 16 (0.08) | |
| LG LG | 1 (0.01) | 1 (0.01) | S | 112 (0.60) | 117 (0.63) | |
| S LA | 33 (0.35) | 30 (0.32) | ||||
| S LG | 17 (0.18) | 7 (0.075) | ||||
| SS | 31 (0.33) | 40 (0.43) | ||||
| Chi square=6.855 df=5 P=0.23 | Chi square=2.43 df=2 P=0.296 | |||||
| Expression based grouping of 5-HTTLPR (L/S) polymorphism and rs25531(A/G) genotypes: | ||||||
| SS, SLG, LG LG (Low) | 49 (0.53) | 48 (0.51) | S or LG (Low) | 137 (0.74) | 133 (0.71) | |
| LA LG, SLA (Medium) | 39 (0.42) | 37 (0.39) | LA (High) | 47 (0.25) | 53 (0.28) | |
| LA LA (High) | 4 (0.04) | 8 (0.08) | ||||
| Chi square=1.39 df=2 P=0.49 | Chi square=0.27 df=1 P=0.6 | |||||