Table 2.

All-Cause and Cause-Specific Standardized Mortality Ratios in 5-Year Survivors of Childhood Cancer

Characteristic	All Causes				Subsequent Malignancy				Cardiac Causes				Pulmonary Causes
	No. of Deaths	SMR	95% CI	P*	No. of Deaths	SMR	95% CI	P*	No. of Deaths	SMR	95% CI	P*	No. of Deaths	SMR	95% CI	P*
All patients	2,076	8.89	8.52 to 9.29		205	8.02	6.96 to 9.19		103	6.05	4.94 to 7.34		29	7.32	4.90 to 10.51
Sex				< .001				.19				.89				.03
Male	1,214	7.64	7.22 to 8.08		104	8.81	7.20 to 10.68		68	6.12	4.75 to 7.75		21	10.10	6.25 to 15.43
Female	862	11.57	10.81 to 12.37		101	7.33	5.97 to 8.91		35	5.93	4.13 to 8.25		8	4.25	1.83 to 8.38
Year of diagnosis				< .001				.04				.03				.83
1974-1980	825	7.52	7.02 to 8.05		121	8.18	6.79 to 9.77		46	4.65	3.40 to 6.20		16	7.70	4.40 to 12.51
1981-1987	617	8.82	8.14 to 9.54		42	6.29	4.53 to 8.51		40	8.72	6.23 to 11.88		8	7.18	3.09 to 14.15
1988-1994	419	10.32	9.36 to 11.36		37	11.63	8.19 to 16.04		15	7.47	4.18 to 12.32		3	5.04	1.01 to 14.72
1995-2000	215	16.35	14.24 to 18.69		5	5.40	1.74 to 12.60		2	3.77	0.42 to 13.63		2	11.47	1.29 to 41.41
Race/ethnicity				< .001				< .001				.15				.19
White	1,699	8.92	8.50 to 9.36		156	7.12	6.05 to 8.33		87	6.41	5.13 to 7.91		22	7.27	4.55 to 11.00
Black	229	6.67	5.84 to 7.59		29	10.72	7.18 to 15.40		11	3.71	1.85 to 6.65		4	5.01	1.35 to 12.83
Asian, Pacific Islander, American Indian, Alaskan native	144	16.60	14.00 to 19.55		20	20.73	12.66 to 32.02		4	8.31	2.24 to 21.28		3	22.25	4.47 to 65.02

NOTE. As of December 31, 2005. All SMRs were age-, sex-, and race-standardized according to the US mortality rates from the SEER Program. “Subsequent malignancy” refers to a new neoplasm. Cancer deaths resulting from progression of the original cancer are not included in the observed number of events.

Abbreviations: SMR, standardized mortality ratio; SEER, Surveillance, Epidemiology, and End Results.

^*P from test for heterogeneity.