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NS8593 inhibition of the KCa3.1T250S+V275A mutant shows reduced calcium-dependence at both 1 μM and 0.1 μM NS8593. Plot of the percentage of current inhibition by NS8593 versus [Ca2+]i concentration for WT KCa2.3 (right) and the KCa3.1T250S+V275A mutant (left). Values are mean ± S.D. (n = 3–15).
