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. 2011 Jun;79(6):1061–1071. doi: 10.1124/mol.111.071456

Fig. 5.

Fig. 5.

κ, But not μ or δ, opioid agonists inhibit spinal neuron spontaneous calcium oscillations. A, control. DAMGO (μ agonist; B) and DPDPE (δ agonist; C) did not affect spontaneous calcium oscillations. D, U69593 (κ agonist) induced suppression of calcium oscillations. E, summary histogram of the data to show that activation of KOR mediates suppression of spinal neuron calcium oscillations. Data represent the mean ± S.E.M. (n = 5) of calcium oscillations before (empty bars) and after compound addition (filled bars). Only the KOR agonist, U69593, suppressed calcium oscillations. *, p < 0.05, paired t test between pre- and postaddition oscillations for U69593. DAMGO and DPDPE did not affect calcium oscillations. F, nonlinear regression analysis of the concentration-response data for U69593-induced suppression of calcium oscillations yielded an IC50 of 38 nM.