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. 2011 Jun;79(6):1061–1071. doi: 10.1124/mol.111.071456

Fig. 6.

Fig. 6.

Summary of κ receptor antagonist block of Dyn-A (1–13) inhibition of calcium oscillations (A and B) and Schild analysis of nor-BNI antagonism (C and D). Data in A and B are the mean ± S.E.M. of calcium oscillations remaining after addition of respective compounds. Pretreatment with nor-BNI or zyklophin eliminated dynorphin-induced suppression of calcium oscillations [n = 5 for nor-BNI experiment; n = 6 for zyklophin experiment; *, p < 0.01, unpaired t test between Dyn-A (1–13) and nor-BNI + Dyn-A (1–13) 300 nM; Dyn-A (1–13) and zyklophin + Dyn-A (1–13) 100 nM]. C, dose-response curves for Dyn-A (1–13) in the absence and presence of fixed concentrations of nor-BNI. D, Schild regression for nor-BNI antagonism of Dyn-A (1–13). Each data point represents the mean of three different experiments.