Table 1.

Non-parametric Linkage Analysis of Various Phenotypes of the 200 Italian Families by Merlin software.

Phenotype	Prevalence	Families	Lod Score	P-value	Empirical P-value
CAD	28.20%	15	1.39	0.006	0.005
Stroke	14.80%	5	1.04	0.014	0.002
Vasculopathy	53.80%	48	0.64	0.040	0.053
Macrovascular Pathology	70.10%	78	2.21	0.0007	0.002

Prevalence = phenotype prevalence among the family subjects studied; Families = families number analyzed; Lod score = derived from the non-parametric linkage analysis by Merlin; Empirical P-value = derived from 1000 replicates by using the gene dropping method; CAD = coronary artery disease; Vasculopathy = based on the presence of plaques and/or angioplasty of carotid arteries, coronary arteries, lower extremities arteries; Macrovascular Pathology = based on the presence of CAD and/or Stroke/TIA and/or Vasculopathy.