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A: neopterin serum levels as function of time and drug dose; B: kyn/trp ratio as function of time and drug dose. Neopterin production (A) and tryptophan degradation (as measured by kynurenine/tryptophan ratio) (B) in patients treated with 22 or 44 mcg of interferon beta-1a (IFNβ-1a), administered three times weekly via subcutaneous injection.
