Table 3. Regulatory proteins are not transcriptionally regulated by Notch.
Microarray Fold Change | mRNA Levels | |||||
DNA Binding Site | Associated Protein | Gene ID | ON/OFF | SD | OFF | ON |
Over-Represented (p-value<0.01) | ||||||
CSL Binding motif | CSL | NM_009035 | 0.8 | 0.2 | 2803.4 | 2179.6 |
Gkfl ZN-FINGER, C2H2 | Klf4 | U20344 | 2.8 | 1.4 | 1582.2 | 4932 |
Pax-4 PAIRED-HOMEO | Pax4 | AF031150 | 2 | 1.1 | 17.6 | 35.1 |
Broad-complex1-4 ZN-FINGER | Kbtbd4 | NM_025991 | 1 | 0 | 2188.4 | 2405.5 |
HNF-3beta FORKHEAD | Foxa2 | NM_010446 | 1.5 | 1.1 | 382.3 | 458.3 |
MZF_1-4ZN-FINGER, C2H2 | Zfp98 | NM_016793 | 1.8 | 1 | 41.2 | 63.3 |
MEF2 MADS | Mef2a | AV255689 | 1 | 0.1 | 4377.5 | 4940 |
Athb- 1 HOMEO-ZIP | Hhex | AK014111 | 0.7 | 0.1 | 8542.9 | 6399.7 |
Nkx HOMEO | Nkx2.5 | NM_008700 | 1.2 | 0.4 | 528.6 | 648 |
NF-Y CAAT-BOX | Nfya | NM_010913 | 0.7 | 0 | 1351.6 | 1077 |
SRY HMG | Sox3 | AF434675 | 0.6 | 0.4 | 148.5 | 52 |
HNF-1 HOMEO | Tcf1/HNF1 | NM_009237 | 4.2 | 4.1 | 111.2 | 277 |
cEBP bZIP | Cebpg | BC011319 | 1.2 | 0.4 | 494 | 596.5 |
Under-represented (p-value>0.99) | ||||||
Yin Yang ZN-FINGER, C2H2 | Yy1 | 0.9 | 0.1 | 11616 | 11426.3 | |
GATA-2 ZN-FINGER, GATA | Gata2 | 1 | 0.1 | 2651.4 | 2815.4 |