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. 2011 May 26;6(5):e20059. doi: 10.1371/journal.pone.0020059

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Annala et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The figure shows how the log-intensity histogram of the Foxo3 PBM sample is changed by quantile normalization. An example of how quantile normalization can recover the high intensity tails in saturated PBM samples. The saturated probe intensities (highlighted in red) are recovered by fitting them to the consensus distribution.