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. 2011 May 26;6(5):e20277. doi: 10.1371/journal.pone.0020277

Figure 1. Olr1 deletion results in broad inhibition of NF-κB target genes.

Figure 1

A diagram depicting a set of overlapping genes between transformation and Olr1 KO transcriptomes. From the set of 238 genes upregulated during transformation, 26 genes were found to be inhibited in Olr1 KO mice. Vast majority of these genes carried NF-κB sites in their proximal promoter sequences. In total, 86 NF-κB target genes were found to be inhibited in Olr1 KO mice with enrichment for regulation of apoptosis (p = 0.0002), proliferation (p = 0.00003), wound healing (p = 0.0002), defense response (p = 0.0011), immune response (p = 0.0003) and cell migration (p = 0.0009).