Table 2. NF-κB target genes outside of transformation pool significantly inhibited in Olr1 knockout mice (more than 1.2-fold).
| Gene Title | Gene Symbola | Fold change | P value | A | W | P | D | M |
| colony stimulating factor 2 | Csf21,2 | -3.55 | 0.0148 | • | • | |||
| phospholipase A2, group IVB (cytosolic) | Pla2g4b1 | -3.29 | 0.0079 | |||||
| lectin, galactose binding, soluble 3 | Lgals31 | -2.93 | 0.0302 | |||||
| BCL 2 related protein A1a | Bcl2a11,2,3 | -2.90 | 0.0304 | • | ||||
| chitinase 3-like 1 | Chi3l12 | -2.80 | 0.0145 | |||||
| lymphotoxin A | Lta1 | -2.73 | 0.0007 | • | • | • | • | |
| hepcidin antimicrobial peptide | Hamp2 | -2.50 | 0.0518 | • | ||||
| immunoglobulin heavy chain complex | Igh2 | -2.34 | 0.0006 | |||||
| glucosaminyl (N-acetyl) transferase 1, core 2 | Gcnt12 | -2.23 | 0.0216 | |||||
| fos-like antigen 2 | Fosl22 | -2.22 | 0.0012 | • | ||||
| NFκB inhibitor, ε | Nfkbie2 | -2.20 | 0.0321 | |||||
| selectin, platelet | Selp1 | -2.20 | 0.0309 | • | • | • | ||
| complement factor B | Cfb1 | -2.15 | 0.0079 | • | • | |||
| deiodinase, iodothyronine, type II | Dio22 | -2.07 | 0.0039 | |||||
| FBJ osteosarcoma oncogene | Fos2 | -2.03 | 0.0270 | |||||
| interleukin 17A | Il17a2 | -2.00 | 0.0103 | • | • | |||
| thrombospondin 1 | Thbs2 | -1.94 | 0.0146 | • | • | • | ||
| CD3 antigen, gamma polypeptide | Cd3g1 | -1.92 | 0.0020 | • | ||||
| LPS-induced TN factor | Litaf3 | -1.91 | 0.0072 | |||||
| CD48 antigen | Cd481 | -1.77 | 0.0228 | |||||
| prostaglandin E synthase | Ptges2 | -1.61 | 0.0484 | • | ||||
| chemokine (C-X-C motif) ligand 5 | Cxcl51 | -1.60 | 0.0055 | • | • | |||
| HSP90, α (cytosolic), class A member 1 | Hsp90aa12 | -1.59 | 0.0355 | |||||
| CD209f antigen | Cd209f2 | -1.56 | 0.0067 | |||||
| vascular cell adhesion molecule 1 | Vcam11,2 | -1.54 | 0.0007 | |||||
| coagulation factor III | F31 | -1.54 | 0.0111 | • | ||||
| twist gene homolog 1 (Drosophila) | Twist12 | -1.52 | 0.0092 | |||||
| B-cell leukemia/lymphoma 2 | Bcl21,2,3 | -1.52 | 0.0201 | • | • | • | • | • |
| cyclin D2 | Ccnd23 | -1.51 | 0.0161 | • | ||||
| dihydropyrimidine dehydrogenase | Dpyd2 | -1.48 | 0.0062 | |||||
| CASP8 and FADD-like apopt. regulator | Cflar1,2,3 | -1.44 | 0.0544 | • | ||||
| related RAS viral oncogene homolog 2 | Rras23 | -1.43 | 0.0476 | • | ||||
| CD274 antigen | Cd2742 | -1.42 | 0.0273 | • | ||||
| immediate early response 3 | Ier31,2,3 | -1.41 | 0.0250 | |||||
| Fas (TNFRSF6)-assoc. via death domain | Fadd3 | -1.39 | 0.0272 | • | ||||
| TNF, alpha-induced protein 3 | Tnfaip31,2,3 | -1.38 | 0.0520 | |||||
| Kruppel-like factor 10 | Klf103 | -1.38 | 0.0267 | • | • | |||
| NUAK family, SNF1-like kinase, 2 | Nuak22 | -1.37 | 0.0300 | • | ||||
| TNF receptor superfamily, member 21 | Tnfrsf211 | -1.35 | 0.0113 | |||||
| interferon regulatory factor 7 | Irf71,2 | -1.35 | 0.0173 | |||||
| transglutaminase 2, C polypeptide | Tgm21 | -1.31 | 0.0390 | • | • | |||
| CD82 antigen | Cd823 | -1.31 | 0.0308 | |||||
| phosphodiesterase 7A | Pde7a2 | -1.31 | 0.0123 | |||||
| heparanase | Hpse2 | -1.29 | 0.0390 | |||||
| ATP-binding cass., subf. B, memb. 1A | Abcb1a1 | -1.28 | 0.0298 | |||||
| midkine | Mdk2 | -1.27 | 0.0502 | • | ||||
| MAD homolog 7 (Drosophila) | Smad73 | -1.27 | 0.0195 | |||||
| solute carrier family 3, member 2 | Slc3a22 | -1.27 | 0.0355 | |||||
| Proteasome subunit, beta type 9 | Psmb91,2 | -1.25 | 0.0264 | |||||
| cyclin D binding myb-like TF 1 | Dmtf12 | -1.25 | 0.0224 | |||||
| beta-2 microglobulin | B2m1,2 | -1.24 | 0.0007 | • | ||||
| adenosine A1 receptor | Adora11 | -1.23 | 0.0215 | • | • | • | ||
| nuclear receptor subf. 3, gr. C, member 1 | Nr3c12 | -1.22 | 0.0540 | • | ||||
| platelet derived GF, B polypeptide | Pdgfb1,2 | -1.22 | 0.0152 | • | • | |||
| cAMP responsive element bind. protein 3 | Creb32 | -1.21 | 0.0306 |
Legend: (a)- a list of NFkB target genes was compiled from the following web-based databases: 1 - http://bioinfo.lifl.fr/NF-KB/; 2 -http://people.bu.edu/gilmore/nf-kb/target/index.html#cyto; and 3 - http://www.broadinstitute.org/mpr/publications/projects/Lymphoma/FF_NFKB_suppl_revised.pdf. The genes whose expression was significantly altered by OLR1 deletion was analyzed for enrichment themes using DAVID bioinformatic database. The enriched themes included regulation of apoptosis, “A”; Wound healing,“W”; Cell proliferation, “P”; Defense response,“D”; Cell migration, “M”.