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. 2011 May 26;6(5):e20374. doi: 10.1371/journal.pone.0020374

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Anthony et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Results of positive and negative controls plotted for 367 representative wells of the alanine racemase assay. The positive control represents 100% inhibition (wells 1–176) and the negative control represents 0% inhibition in the presence of 1% DMSO (wells 177–367). (B) HTS data for one of the two replicates for the entire 53,000-compound screen, obtained from 138 384-well plates. The line indicates the 30% inhibition cut-off for hit selection. A similar distribution of positive and negative controls results were obtained for the coupling enzyme assay (data not shown). (C) Distribution of the 267 hits, with the hits categorized into 7 groups with respect to percent inhibition.