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. 2011 May 26;6(5):e20480. doi: 10.1371/journal.pone.0020480

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Vrana et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Distribution of 3T3 fibroblast after 7 day of culture from back to front for (Left hand side) Titanium Titanium/PLLA hybrid (Right hand side). Last images shows the depth through the scaffold where the signal (cell number) decreases significantly (∼350 µm and 200 µm respectively). Cells were able to move towards the front surface of the implant for both scaffold but the number of cells significantly decreased towards the front; where the migration degree was much higher in titanium scaffolds.