Table 2. Main results of pooled ORs and stratification analysis of the miR-196a2 C/T (rs11614913) and miR-146a G/C (rs2910164) functional polymorphisms on cancer risk in the meta-analysis.
miR-196a2 | TT vs CC | CT vs CC | T vs C | Dominant model | Recessive model | |
C/T | N | OR (95% CI) Ph | OR (95% CI) Ph | OR (95% CI) Ph | OR (95% CI) Ph | OR (95% CI) Ph |
Total | 11 | 0.92(0.85–0.99)0.45 | 0.98(0.93–1.03)0.87 | 0.96(0.92–0.99)0.61 | 0.97(0.93–1.02)0.93 | 0.90(0.84–0.97)0.50 |
Cancer types | ||||||
Breast | 3 | 0.84(0.78–1.05)0.08 | 0.97(0.89–1.06)0.82 | 0.94(0.88–0.99)0.26 | 0.96(0.89–1.03)0.73 | 0.83(0.77–1.03)0.07 |
Lung | 2 | 0.88(0.75–1.04)0.74 | 0.94(0.83–1.07)0.99 | 0.94(0.86–1.02)0.71 | 0.95(0.86–1.05)0.91 | 0.91(0.78–1.05)0.57 |
Liver | 2 | 0.93(0.72–1.19)0.29 | 0.98(0.80–1.19)0.71 | 0.96(0.84–1.09)0.24 | 0.97(0.82–1.15)0.60 | 0.92(0.72–1.16)0.15 |
Others | 4 | 1.01(0.87–1.18)0.69 | 1.02(0.92–1.04)0.29 | 0.99(0.92–1.07)0.53 | 1.00(0.93–1.02)0.48 | 0.95(0.83–1.10)0.87 |
Ethnicity | ||||||
Caucasian | 4 | 0.94(0.82–1.07)0.10 | 0.99(0.91–1.07)0.51 | 0.96(0.91–1.02)0.21 | 0.98(0.91–1.05)0.52 | 0.92(0.81–1.04)0.09 |
Asian | 7 | 0.91(0.82–1.00)0.75 | 0.97(0.89–1.05)0.84 | 0.95(0.90–0.99)0.74 | 0.97(0.91–1.03)0.91 | 0.90(0.82–0.98)0.85 |
N indicates number of studies involved; Ph: P-value of Q-test for heterogeneity test.