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. 2011 May 26;6(5):e20471. doi: 10.1371/journal.pone.0020471

Table 2. Main results of pooled ORs and stratification analysis of the miR-196a2 C/T (rs11614913) and miR-146a G/C (rs2910164) functional polymorphisms on cancer risk in the meta-analysis.

miR-196a2 TT vs CC CT vs CC T vs C Dominant model Recessive model
C/T N OR (95% CI) Ph OR (95% CI) Ph OR (95% CI) Ph OR (95% CI) Ph OR (95% CI) Ph
Total 11 0.92(0.85–0.99)0.45 0.98(0.93–1.03)0.87 0.96(0.92–0.99)0.61 0.97(0.93–1.02)0.93 0.90(0.84–0.97)0.50
Cancer types
Breast 3 0.84(0.78–1.05)0.08 0.97(0.89–1.06)0.82 0.94(0.88–0.99)0.26 0.96(0.89–1.03)0.73 0.83(0.77–1.03)0.07
Lung 2 0.88(0.75–1.04)0.74 0.94(0.83–1.07)0.99 0.94(0.86–1.02)0.71 0.95(0.86–1.05)0.91 0.91(0.78–1.05)0.57
Liver 2 0.93(0.72–1.19)0.29 0.98(0.80–1.19)0.71 0.96(0.84–1.09)0.24 0.97(0.82–1.15)0.60 0.92(0.72–1.16)0.15
Others 4 1.01(0.87–1.18)0.69 1.02(0.92–1.04)0.29 0.99(0.92–1.07)0.53 1.00(0.93–1.02)0.48 0.95(0.83–1.10)0.87
Ethnicity
Caucasian 4 0.94(0.82–1.07)0.10 0.99(0.91–1.07)0.51 0.96(0.91–1.02)0.21 0.98(0.91–1.05)0.52 0.92(0.81–1.04)0.09
Asian 7 0.91(0.82–1.00)0.75 0.97(0.89–1.05)0.84 0.95(0.90–0.99)0.74 0.97(0.91–1.03)0.91 0.90(0.82–0.98)0.85

N indicates number of studies involved; Ph: P-value of Q-test for heterogeneity test.