Figure 7. RV1B-induced IFN responses and viral titer in OVA-treated MDA5−/− mice.

OVA-treated MDA5−/− mice and control mice were infected with sham or RV1B. Total lungs were harvested at 24 post infection. A–C The expression of IFN-β, IFN-λ2, IFN-λ3 was determined by qPCR. D. Total lung titer at 24 h post infection was determined by plaque assay. The expression of each target gene was normalized to GAPDH. Data represent mean ± SEM for five-seven mice.