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. 2011 May 26;7(5):e1002085. doi: 10.1371/journal.pgen.1002085

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Nishino et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Decrease in the number of the ES-iPS-DMRs with continuous passaging. Upper panels show change of the number of the ES-iPS-DMRs (left), the inherited regions (middle) and aberrant regions (right) on whole genome. Lower panels show change in the number of the ES-iPS-DMRs (left), inherited regions (middle) and aberrant regions (right) on X chromosome. The number of the ES-iPS-DMRs in XX-iPSCs approached zero with continuous passaging on X chromosome. In contrast, XY-iPSCs had few ES-iPS-DMRs on X chromosome throughout the passages. (B) The number of the ES-parent-DMRs with continuous passaging. (C) No expression of the transgenes in iPSCs at each passage was detected by RT-PCR.