Table 1. List of the top 20 out of 82 transcription factor genes with hypo-methylated stem cell-required DMRs exhibiting “high” expression in human iPS cells.
| DNA methylation | ||||
| TargetID | Gene name | HUESCs | iPSCs | Expression level |
| cg13083810 | POU5F1, POU domain; class 5; transcription factor 1 isoform 1 | 0.584 | 0.549 | 55543.9 |
| cg06303238 | SALL4, sal-like 4 | 0.032 | 0.026 | 29766.2 |
| cg16990174 | RYBP, RING1 and YY1 binding protein | 0.076 | 0.119 | 10274.1 |
| cg03589001 | MORF4L1, MORF-related gene 15 isoform 2 | 0.176 | 0.173 | 7015.7 |
| cg02204046 | MYCN, v-myc myelocytomatosis viral related oncogene; neuroblastoma derived | 0.022 | 0.027 | 5826.8 |
| cg10705800 | CITED4, Cbp/p300-interacting transactivator; with Glu/Asp-rich carboxy-terminal domain; 4 | 0.438 | 0.445 | 5342.2 |
| cg21696393 | SOX8, SRY (sex determining region Y)-box 8 | 0.074 | 0.061 | 1976.7 |
| cg23131007 | TCF12, transcription factor 12 isoform b | 0.138 | 0.155 | 1930.7 |
| cg18808261 | SATB1, special AT-rich sequence binding protein 1 | 0.194 | 0.242 | 1634.4 |
| cg15607672 | OTX2, orthodenticle 2 isoform a | 0.046 | 0.054 | 1227.5 |
| cg05345286 | MDFI, MyoD family inhibitor | 0.023 | 0.040 | 1035.9 |
| cg20909686 | OVOL1, OVO-like 1 binding protein | 0.215 | 0.204 | 991.0 |
| cg26209676 | ZNF581, zinc finger protein 581 | 0.113 | 0.196 | 916.1 |
| cg05522383 | PITX2, paired-like homeodomain transcription factor 2 isoform b | 0.024 | 0.030 | 544.8 |
| cg17675150 | ZNF532, zinc finger protein 532 | 0.069 | 0.107 | 525.3 |
| cg01510051 | ZNF542, zinc finger protein 542 | 0.585 | 0.555 | 443.9 |
| cg06154570 | HEYL, hairy/enhancer-of-split related with YRPW motif-like | 0.134 | 0.152 | 440.3 |
| cg12556134 | TGIF2, TGFB-induced factor 2 | 0.075 | 0.072 | 405.4 |
| cg03663715 | FOXD1, forkhead box D1 | 0.030 | 0.042 | 349.1 |
| cg09721427 | HHEX, hematopoietically expressed homeobox | 0.077 | 0.101 | 206.9 |
“Expression level” is an average of raw data values in iPSCs from Gene Chip data.