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. 2011 May 26;7(5):e1002071. doi: 10.1371/journal.pgen.1002071

Figure 3. ChIP and expression profiling of control and Hoxc−/− MEFs.

Figure 3

Enrichment of tri-methylated H3K27 over the HoxD gene cluster in both control mice and mice carrying a deletion of the HoxC cluster. The presence of this histone modification is assayed by qPCR after chromatin immunoprecipitation, either from dissected fetal hindbody (A) or from fetal hindlimbs at E13.5 (B). (C) Quantification of Hoxd gene transcripts present in either control, or HoxC mutant mouse embryonic fibroblasts (MEFs). (D) Comparison of H3K27me3 coverage between control and HoxC mutant-derived MEFs.