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Experimental data (small tissue preparations) are white squares. A) Steady state APD90 rate dependence. From left to right, top to bottom: N = 140, 5, 5, 5, 5, 4, and 4 hearts. Shown are control, IKr, IKs, ICaL, IK1, RyR, and late INa block. B) APD90 restitution (S1 = 1000 ms). From left to right: N = 50, 3, and 4 hearts. Shown are control, IKr, and IKs block.
