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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Nat Neurosci. 2011 Apr 24;14(6):727–735. doi: 10.1038/nn.2804

Figure 3.

Figure 3

Phosphorylation of GluA1-Ser831 changes γMEAN independent of agonist efficacy. A. Example of macroscopic currents and isolated difference currents for glutamate and willardiine activation of recombinant GluA1-L497Y in the same patch from HEK cells. B. Structures of the agonists used. C. The current-variance relationships are superimposed for glutamate and willardiine. D. There is a correlation (R = 0.95, p = 0.001) between the maximal response induced by agonists (expressed as a ratio to current induced by maximally effective glutamate) and the γMEAN obtained from variance analysis. Data are from 5–22 patches for each agonist.