. Author manuscript; available in PMC: 2011 Dec 1.

Published in final edited form as: Nat Neurosci. 2011 Apr 24;14(6):727–735. doi: 10.1038/nn.2804

Table 3.

Effect of Ser831 phosphomutations on recombinant homomeric GluA1 receptor coupling efficiency, ε

	γ_MEAN (pS)	ε	γ_MEAN (pS)	ε	Δε	N
	Control		CaMKII

GluA1^a	12.0 ± 1.0	0.45	20.4 ± 2.9	0.84	0.39	9, 11
GluA1-L497Y^b	12.4 ± 0.3	0.47	17.6 ± 0.4	0.71	0.24	19, 22
	S831A,S845A		S831E,S845A

GluA1^b,^c	8.3 ± 0.6	0.24	13.9 ± 0.9	0.54	0.30	23, 11
GluA1- L497Y^b	9.4 ± 0.7	0.29	14.2 ± 0.6	0.54	0.25	18, 19

Homomeric GluA1 macroscopic current responses in outside-out patches from HEK cells were induced by 1 mM glutamate followed by a slow washout. Variance analysis of the response was used to estimate weighted mean conductance (γ_MEAN). Values are mean ± SEM.

Non-stationary variance analysis from Table 1

Stationary variance analysis

Currents recorded in the presence of 100 μM cyclothiazide