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. Author manuscript; available in PMC: 2011 Nov 26.
Published in final edited form as: Nature. 2011 May 1;473(7348):528–531. doi: 10.1038/nature09968

Figure 1. Proteomic and lipidomic landscape of the lean and obese ER.

Figure 1

a, Biological pathways associated with significantly regulated proteins in the obese ER proteome. Bar colors indicate the fold enrichment with significance values (negative log of p-values) superimposed. b,c, Transcript levels of genes involved in lipid metabolism in the lean and obese mouse liver. d, Alterations of liver ER lipidome. Heatmap display of all significant (p<0.05) alterations present between lean and obese ER lipidomes. The color corresponds to differences in the relative abundance (nmol%) of each fatty acid among individual lipid groups detected in the lean and obese liver ER. e, The relative abundance of PC and PE in lean and obese liver ER samples. Values are mean±SEM (n=6 for each group). “*” denotes p<0.05, Student's t-test.